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https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/eef8732b-a97a-435a-ada9-1a8fb840d2cf/IMG_7151.jpg lab members https://www.eckmaslab.com/researchoverview daily 0.75 2026-01-08 https://www.eckmaslab.com/publications daily 0.75 2026-03-25 https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/e3a0940f-4d76-4628-bf8e-ce5674949194/DPPA2%3A4_NSCLC.webp publications - Embryonic stem cell factors DPPA2/4 amplify active H3K4me3–H2AK119ub chromatin domains in non-small cell lung cancer Janith A Seneviratne, Clare L Crisp, Eleanor Glancy, Natalie Choy, Winnie Tan, Matthew Neve, Melanie Stammers, Tongtong Wang, Ruby Johnstone, Arshnoor Kaur, Katie A Fennell, Marian Burr, Benjamin Parker, Shabih Shakeel, and Melanie A Eckersley-Maslin Genes and Development 2026 article preprint Peter Mac press release UoM press release https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/eaced1da-04bb-4698-bd8e-b9c117c15634/Screenshot+2024-02-10+at+3.07.05%E2%80%AFpm.png publications - A low‑input high resolution sequential chromatin immunoprecipitation method captures genome‑wide dynamics of bivalent chromatin Janith A Seneviratne*, William Ho*, Eleanor Glancy and Melanie A Eckersley-Maslin Epigenetics and Chromatin 2024 preprint article EpiGenie Article protocol.io https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/f7beff71-2f08-493a-bcd3-4eb67272132d/BivalentChromatinTippedCancer.png publications - Bivalent chromatin: a developmental balancing act tipped in cancer Eleanor Glancy, Natalie Choy and Melanie Eckersley-Maslin Biochemical Society Transactions 2024 article https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/366a1d73-f183-4ff3-b5bd-089d58f87317/Screenshot+2024-08-28+at+11.55.23%E2%80%AFam.png publications - Exploring the Stability of Genomic Imprinting and X-Chromosome Inactivation in the Aged Brain Samantha Mancino+, Janith Seneviratne+, Annalisa Mupo, Felix Krueger, David Oxley, Melanie A. Eckersley-Maslin,* and Simão Teixeira da Rocha* Aging Biology 2024 article https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/1632985576237-M6CI0OKCQ03NSXPQMFAW/Screenshot+2021-09-30+at+16.37.55.png publications - Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival Oana Kubinyecz, Fatima Santos, Deborah Drage, Wolf Reik* and Melanie Eckersley-Maslin* Development 2021 preprint highlight article https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/1625028469475-UG1RYMGPT1QDJ278QKSK/CRISPRa+screen publications - Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells Celia Alda-Catalinas, Mélanie A. Eckersley-Maslin and Wolf Reik STAR protocols 2021 article https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/1608460193570-PM46EXEVENAVP89ZODQE/Dppa_priming_review publications - Keeping your options open: insights from Dppa2/4 into how epigenetic priming factors promote cell plasticity Mélanie A. Eckersley-Maslin Biochemical Society Transactions 2020 article https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/1600198809484-KB4IYNA1GS8FPHTAZ7M6/EckersleyMaslin_priming publications - Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment Mélanie A. Eckersley-Maslin*, Aled Parry, Marloes Blotenburg, Christel Krueger, Yoko Ito, Valar Nila Roamio Franklin, Masashi Narita, Clive S. D’Santos and Wolf Reik* Nature Structural and Molecular Biology 2020 preprint article press release https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/1600174767055-SK1TO8RPO4FCUT1HUZIM/Alda-Catalinas_CRISPR publications - A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program Celia Alda-Catalinas, Danila Bredikhin, Irene Hernando-Herraez, Fátima Santos, Oana Kubinyecz, Mélanie A. Eckersley-Maslin*, Oliver Stegle*and Wolf Reik* Cell Systems 2020 preprint article press release https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/1601494031432-0068XY4NPR71I0W9EEF8/Screenshot+2020-09-30+at+20.26.44.png publications - IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions Tajda Klobučar, Elisa Kreibich, Felix Krueger, Maria Arez, Duarte Pólvora-Brandão, Ferdinand von Meyenn, Simão Teixeira da Rocha*, Melanie Eckersley-Maslin* Nucleic Acids Research 2020 preprint article press release https://images.squarespace-cdn.com/content/v1/5f5e24218e9f9752686ef819/1600175052360-IGJAU5LTQGU829N9TZFF/EckersleyMaslin_ZGA publications - Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program Mélanie Eckersley-Maslin*, Celia Alda-Catalinas, Marloes Blotenburg, Elisa Kreibich, Christel Krueger and Wolf Reik* Genes and Development 2018 preprint article press release https://www.eckmaslab.com/science-links 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